Na-K-ATPase which is a enzyme responsible for the active transport of Na and K. ions through cell membrane, is present in high concentrations in the train and other nervous tissues. And it plays several roles in the complex and fine control of ionic environment which underlies nerve activity, and it maintains the ion gradients of Na and K which are the energy source for the nerve impulse.
This study was attempted to investigate the effects of tetracaine, dopamine, ephedrine, and ketamine ·on Na-K-ATPase activity in the homogenate of rabbit cerebral cortex.
The results to study were summarized as follows :
1. The average activity of Na-K-ATPase in the rabbit cerebral cortex was approximate 4mMPi/L/10min.
2. Tetracaine(1.0mg/ml) , dopamine(10.0mg/ml), and ephedrine(8.0mg/ml) were significantly inhibited the Na-K-ATPase activity, respectively.
3. Ketamine was significantly activated the Na-K-ATPase activity at the concentration of 5.0mg/ml, hut it was significantly inhibited the Na-K-ATPase activity at 25.0mg/ml.
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